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KMID : 0923620140140040171
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Immune Network
2014 Volume.14 No. 4 p.171 ~ p.181
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The Roles of Innate Lymphoid Cells in the Development of Asthma
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Woo Yeon-Duk
Jeong Dong-Jin
Chung Doo-Hyun
Kim Hye-Young
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Abstract
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Asthma is a common pulmonary disease with several differ-ent forms. The most studied form of asthma is the allergic form, which is mainly related to the function of Th2 cells and their production of cytokines (IL-4, IL-5, and IL-13) in associa-tion with allergen sensitization and adaptive immunity. Recently, there have been many advances in understanding non-allergic asthma, which seems to be related to environ-mental factors such as air pollution, infection, or even obesity. Cells of the innate immune system, including macro-phages, neutrophils, and natural killer T cells as well as the newly described innate lymphoid cells, are effective pro-ducers of a variety of cytokines and seem to play important roles in the development of non-allergic asthma. In this re-view, we focus on recent findings regarding innate lymphoid cells and their roles in asthma.
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KEYWORD
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Airway hyperreactivity, Asthma, Innate lymphoid cells, Allergic asthma, Non-allergic asthma
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